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Neuro Startup Challenge Inventions

Winners of the Challenge  will need to negotiate a NIH license per the federal statutes and regulations, including 35 USC 209 and 37 CFR 404

Invention #1(5/30)
Invention #2 (10/30)
Invention #3 (4/30)

Invention #4 (3/30)
Invention #5 (2/30)
Invention #6 (9/30)
Invention #7 (1/30)
Invention #8 (6/30)
Invention #9 (9/30)
Invention #10 (5/30)
Invention #11 (1/30)
Invention #12 (0/30)
Invention #13 (4/30)
Invention #14 (3/30)
Invention #15 (5/30)
Invention #16 (7/30)


Neurological Diseases and Cognitive Disorders

#1 - A novel compound for treatment of disorders with cognitive dysfunction for example attention-deficit/hyperactivity disorder 
  • Invention Type: Therapeutic
  • Patent Status:  US Application No. 61/774,878 
  • LINK: http://www.ott.nih.gov/technology/E-073-20130
  • NIH Reference Number: E-073-2013
  • NIH Institute or Center: National Institute on Drug Abuse (NIDA)

#2 - A novel therapy for neurodegenerative diseases for example Alzheimer’s disease 
  • Invention Type: Therapeutic
  • Patent Status: US Patent Grant No. US 8597660 B2
  • LINK: http://www.ott.nih.gov/technology/E-144-20100
  • NIH Reference Number: E-144-2010
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#3 - A method of treating an enzyme deficiency disorders which causes neurodegeneration with small molecule
  • Invention Type: Therapeutic/Method
  • Patent Status: US Patent Application No. 14/110,393 filed 07 and EP Patent Application No. 12716889.6 
  • LINK: http://www.ott.nih.gov/technology/e-157-20110
  • NIH Reference Number: E-157-2011
  • NIH Institute or Center: National Institute of Child Health and Human Development (NICHD) 

#4 - Novel Dopamine D2 Receptor Antagonists and Methods of Their Use
  • Invention Type: Therapeutic
  • Patent Status: US application filed in 2013, pending approval 
  • LINK: http://www.ott.nih.gov/technology/e-030-20130
  • NIH Reference Number: E-030-2013
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

Brain Injury

#5 - A device to simulate the impact of brain trauma for explosive blast-induced Traumatic Brain Injury (TBI) and early stage TBI diagnosis
  • Invention Type: Device and Diagnostic
  • Patent Status:  US Application No. 61/590,209 and 13/748,410 
  • LINKs:  http://goo.gl/rLXGni, http://goo.gl/XLeQCa
  • NIH Reference Number: E-068-2012
  • NIH Institute or Center: National Institute of Child Health and Human Development (NICHD) 

#6 - A novel drug delivery method for treatment of brain injury and disease - focusing on Central Nervous System (CNS) disorders, such as stroke, hemorrhage, or TBI
  • Invention Type: Therapeutic and Method
  • Patent Status: US Application No. 61/599,107, PCT Application No. PCT/US13/24741
  • LINK: http://goo.gl/ee3Kyl
  • NIH Reference Number: E-025-2012
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#7 - A novel treatment for vascular disease/injury/inflammation in vasculature such as carotid artery which supplies blood to the brain

  • Invention Type: Therapeutic
  • Patent Status: US Application No. 61/582,574, PCT Application No. PCT/US2013/020103
  • LINK: http://link.springer.com/article/10.1007%2Fs00109-013-1091-4
  • NIH Reference Number: E-165-2011
  • NIH Institute or Center: National Institute on Aging (NIA)

Brain Cancer

#8 - A brain cancer specific target which can be used in diagnostics and potentially therapeutic applications
  • Invention Type: Class III Diagnostics and potentially Therapeutics
  • Patent Status:  US Application No. 13/322,863; PCT Application No. PCT/US2010/36394; US Application No. 61/182,072
  • LINK:  http://www.ott.nih.gov/technology/e-178-20090
  • NIH Reference Number:  E-178-2009
  • NIH Institute or Center: National Cancer Institute (NCI)

#9 - A tumor diagnostic marker for new blood vessels formation which can be used for early detection of brain tumors
  • Invention Type: Class III Diagnostics
  • Patent Status: PCT Application No. PCT/US2007/072395, US Application No. 60/879,457,  60/858,068,  13/863,674, 12/514,297.U.S. Pat: 8,440,411 issued
  • LINK: https://www.google.com/patents/US8440411?dq=8,440,411&hl=en&sa=X&ei=ODqvU5XBCsyNyAT_poDIDg&ved=0CBwQ6AEwAA
  • NIH Reference Number:  E-285-2006
  • NIH Institute or Center: National Cancer Institute (NCI)

#10 - A new compound for treatment of Neurofibromatosis Type 1
  • Invention Type: Diagnostic, Therapeutic
  • Patent Status: US Patent Grant No. 8,686,016; European and Australian PCT Application No. 2010242874 
  • LINK: http://www.ott.nih.gov/technology/e-183-20090
  • NIH Reference Number: E-183-2009
  • NIH Institute or Center: National Cancer Institute (NCI)

MRI Improvement

Teams should consider developing the following MRI related inventions in logical bundles or separately. Note that if more than one invention is selected to create deliverables, all deliverables should illustrate how inventions will create synergies and/or are complementary 
#11 - A novel radio frequency coil circuitry scheme to obtain better signal to noise ratio in MRI
  • Invention Type: Class II Device
  • Patent Status: PCT Application No. PCT/US2007/008586, US Application No. 60/789,934, U.S. Pat: 7,932,721 issued 2011-04-26
  • LINK: http://www.ott.nih.gov/technology/e-099-20060
  • NIH Reference Number: E-099-2006
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#12 - A specific radio frequency coil system which improves the resolution of high-field MRI
  • Invention Type: Class II Device 
  • Patent Status: US Application No. 60/900,972, PCT Application No. PCT/US2008/001911, U.S. Pat: 8,125,225 issued 2012-02-28
  • LINK: http://www.ott.nih.gov/technology/e-020-20070
  • NIH Reference Number:  E-020-2007
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#13 - A MRI invention that improves several facets of MRI usage to help in several capacities such as guided surgery
  • Invention Type: Class II or Class III Device depending on the team's creativity
  • Patent Status: PCT Application No. PCT/US2012/31083, US Application No. 61/468,911, US Application No. 14/008,133
  • LINK: http://www.ott.nih.gov/technology/e-113-20110
  • NIH Reference Number: E-113-2011
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#14 - A motion correction method to reduce MRI artifacts during brain inspection
  • Invention Type: Class II Device
  • Patent Status: US Application No. 61/045,782, PCT Application No. PCT/US09/40948, US Application No. 12/937,852
  • LINK:  http://www.ncbi.nlm.nih.gov/pubmed/19526503; http://www.ott.nih.gov/technology/e-144-20080
  • NIH Reference Number: E-144-2008
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

Teams should consider developing this invention without combining it with any other MRI related inventions.
#15 - A novel MRI contrast agent to improve the visibility of internal body structures during MR imaging
  • Invention Type: Device
  • Patent Status: U.S. Applications filed on April 18, 2008 (US Application No. 61/071,263; US Application No. 61/166,610; US Application No. 12/937,843); PCT Application filed on April 18, 2008 (PCT Application No. PCT/US2009/041142)
  • LINK: http://www.ott.nih.gov/technology/e-081-20080
  • NIH Reference Number: E-081-2008
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Standards and Technology (NIST)

Viruses

#16 - Methods and Composition for Identification of Variants of JC Virus DNA for  the Diagnostics and Prevention of Progressive Multifocal Leukoencephalopathy (PML)
  • Invention Type: Diagnostics
  • Patent status: PCT application (PCT/US2013/046158) filed June 17, 2013 
  • LINK: http://www.ott.nih.gov/technology/e-088-20120
  • NIH Reference Number: E-088-2012
  • NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)
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