Inventions

Neuro Startup Challenge Inventions

Winners of the Challenge will need to negotiate a NIH license per the federal statutes and regulations, including 35 USC 209 and 37 CFR 404

Invention #1(5/30)
Invention #2 (10/30)
Invention #3 (4/30)
Invention #4 (3/30)

Invention #5 (2/30)
Invention #6 (9/30)
Invention #7 (1/30)
Invention #8 (6/30)

Invention #9 (9/30)
Invention #10 (5/30)
Invention #11 (1/30)
Invention #12 (0/30)

Invention #13 (4/30)
Invention #14 (3/30)
Invention #15 (5/30)
Invention #16 (7/30)

Neurological Diseases and Cognitive Disorders

#1 - A novel compound for treatment of disorders with cognitive dysfunction for example attention-deficit/hyperactivity disorder

Invention Type: Therapeutic
Patent Status: US Application No. 61/774,878
LINK: http://www.ott.nih.gov/technology/E-073-20130
NIH Reference Number: E-073-2013
NIH Institute or Center: National Institute on Drug Abuse (NIDA)

#2 - A novel therapy for neurodegenerative diseases for example Alzheimer’s disease

Invention Type: Therapeutic
Patent Status: US Patent Grant No. US 8597660 B2
LINK: http://www.ott.nih.gov/technology/E-144-20100
NIH Reference Number: E-144-2010
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#3 - A method of treating an enzyme deficiency disorders which causes neurodegeneration with small molecule

Invention Type: Therapeutic/Method
Patent Status: US Patent Application No. 14/110,393 filed 07 and EP Patent Application No. 12716889.6
LINK: http://www.ott.nih.gov/technology/e-157-20110
NIH Reference Number: E-157-2011
NIH Institute or Center: National Institute of Child Health and Human Development (NICHD)

#4 - Novel Dopamine D2 Receptor Antagonists and Methods of Their Use

Invention Type: Therapeutic
Patent Status: US application filed in 2013, pending approval
LINK: http://www.ott.nih.gov/technology/e-030-20130
NIH Reference Number: E-030-2013
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

Brain Injury

#5 - A device to simulate the impact of brain trauma for explosive blast-induced Traumatic Brain Injury (TBI) and early stage TBI diagnosis

Invention Type: Device and Diagnostic
Patent Status: US Application No. 61/590,209 and 13/748,410
LINKs: http://goo.gl/rLXGni, http://goo.gl/XLeQCa
NIH Reference Number: E-068-2012
NIH Institute or Center: National Institute of Child Health and Human Development (NICHD)

#6 - A novel drug delivery method for treatment of brain injury and disease - focusing on Central Nervous System (CNS) disorders, such as stroke, hemorrhage, or TBI

Invention Type: Therapeutic and Method
Patent Status: US Application No. 61/599,107, PCT Application No. PCT/US13/24741
LINK: http://goo.gl/ee3Kyl
NIH Reference Number: E-025-2012
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#7 - A novel treatment for vascular disease/injury/inflammation in vasculature such as carotid artery which supplies blood to the brain

Invention Type: Therapeutic
Patent Status: US Application No. 61/582,574, PCT Application No. PCT/US2013/020103
LINK: http://link.springer.com/article/10.1007%2Fs00109-013-1091-4
NIH Reference Number: E-165-2011
NIH Institute or Center: National Institute on Aging (NIA)

Brain Cancer

#8 - A brain cancer specific target which can be used in diagnostics and potentially therapeutic applications

Invention Type: Class III Diagnostics and potentially Therapeutics
Patent Status: US Application No. 13/322,863; PCT Application No. PCT/US2010/36394; US Application No. 61/182,072
LINK: http://www.ott.nih.gov/technology/e-178-20090
NIH Reference Number: E-178-2009
NIH Institute or Center: National Cancer Institute (NCI)

#9 - A tumor diagnostic marker for new blood vessels formation which can be used for early detection of brain tumors

Invention Type: Class III Diagnostics
Patent Status: PCT Application No. PCT/US2007/072395, US Application No. 60/879,457, 60/858,068, 13/863,674, 12/514,297.U.S. Pat: 8,440,411 issued
LINK: https://www.google.com/patents/US8440411?dq=8,440,411&hl=en&sa=X&ei=ODqvU5XBCsyNyAT_poDIDg&ved=0CBwQ6AEwAA
NIH Reference Number: E-285-2006
NIH Institute or Center: National Cancer Institute (NCI)

#10 - A new compound for treatment of Neurofibromatosis Type 1

Invention Type: Diagnostic, Therapeutic
Patent Status: US Patent Grant No. 8,686,016; European and Australian PCT Application No. 2010242874
LINK: http://www.ott.nih.gov/technology/e-183-20090
NIH Reference Number: E-183-2009
NIH Institute or Center: National Cancer Institute (NCI)

MRI Improvement

Teams should consider developing the following MRI related inventions in logical bundles or separately. Note that if more than one invention is selected to create deliverables, all deliverables should illustrate how inventions will create synergies and/or are complementary
#11 - A novel radio frequency coil circuitry scheme to obtain better signal to noise ratio in MRI

Invention Type: Class II Device
Patent Status: PCT Application No. PCT/US2007/008586, US Application No. 60/789,934, U.S. Pat: 7,932,721 issued 2011-04-26
LINK: http://www.ott.nih.gov/technology/e-099-20060
NIH Reference Number: E-099-2006
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#12 - A specific radio frequency coil system which improves the resolution of high-field MRI

Invention Type: Class II Device
Patent Status: US Application No. 60/900,972, PCT Application No. PCT/US2008/001911, U.S. Pat: 8,125,225 issued 2012-02-28
LINK: http://www.ott.nih.gov/technology/e-020-20070
NIH Reference Number: E-020-2007
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#13 - A MRI invention that improves several facets of MRI usage to help in several capacities such as guided surgery

Invention Type: Class II or Class III Device depending on the team's creativity
Patent Status: PCT Application No. PCT/US2012/31083, US Application No. 61/468,911, US Application No. 14/008,133
LINK: http://www.ott.nih.gov/technology/e-113-20110
NIH Reference Number: E-113-2011
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

#14 - A motion correction method to reduce MRI artifacts during brain inspection

Invention Type: Class II Device
Patent Status: US Application No. 61/045,782, PCT Application No. PCT/US09/40948, US Application No. 12/937,852
LINK: http://www.ncbi.nlm.nih.gov/pubmed/19526503; http://www.ott.nih.gov/technology/e-144-20080
NIH Reference Number: E-144-2008
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS)

Teams should consider developing this invention without combining it with any other MRI related inventions.
#15 - A novel MRI contrast agent to improve the visibility of internal body structures during MR imaging

Invention Type: Device
Patent Status: U.S. Applications filed on April 18, 2008 (US Application No. 61/071,263; US Application No. 61/166,610; US Application No. 12/937,843); PCT Application filed on April 18, 2008 (PCT Application No. PCT/US2009/041142)
LINK: http://www.ott.nih.gov/technology/e-081-20080
NIH Reference Number: E-081-2008
NIH Institute or Center: National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Standards and Technology (NIST)

Viruses

#16 - Methods and Composition for Identification of Variants of JC Virus DNA for the Diagnostics and Prevention of Progressive Multifocal Leukoencephalopathy (PML)